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filingDate 2003-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2005-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2005538742-A
titleOfInvention Hematopoietic stem cells and methods of treating neovascular diseases of the eye using the cells
abstract An isolated, mammalian, bone marrow-derived, lineage-negative hematopoietic stem cell population (Lin - HSC) contains endothelial progenitor cells (EPCs) capable of forming retinal blood vessels. At least about 50% of the cells of the isolated Lin HSC population have CD31 and c-kit cell surface markers. Up to about 8% of cells can have a Sca-1 cell marker and up to about 4% of cells can have a Flk-1 / KDR marker. The isolated Lin HSC population of the present invention is useful for treating ocular vascular disease. Also provided is an isolated Lin HSC population transfected with a therapeutically useful gene, which is useful for delivering genes to the eye in cell-based gene therapy.
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