| abstract |
The present invention relates to formula I [Chemical 1] (Wherein A, R 2 , R 3 , R 4 , R 5 and n have the meanings indicated in the claims). The compounds of formula I are valuable pharmaceutically active compounds that are useful in the treatment of various disease states including cardiovascular diseases such as atherosclerosis, thrombosis, coronary artery disease, hypertension and heart failure. They upregulate the expression of the enzyme endothelial nitric oxide (NO) synthase and can be applied in situations where increased expression of the enzyme or increased or decreased NO levels or normalization of reduced NO levels is required. The invention further relates to a process for the preparation of the compounds of formula I, in particular the use of said compounds as active pharmaceutical ingredients and pharmaceutical formulations containing said compounds. |