| abstract |
The present invention relates to novel methods for detecting or treating abnormal cell cycle control associated with the expression of a nuclear protein encoded by a gene linked to map position 8q22.3 of the human genome, and novel reagents useful therefor. More particularly, the present invention relates to novel nucleic acids and protein probes for detecting a gene linked to map position 8q22.3 of the human genome or an expression product thereof, wherein the expression or increased expression of said gene is cancer, DNA damage And the appearance or development of tumors associated with progesterone receptor-mediated effects on cells. The present invention also provides reagents and methods for detecting or modulating gene expression products such as cell proliferation, DNA damage or progesterone receptor-mediated effects on cells, eg, in cancer diagnostic or therapeutic treatment. |