| abstract |
The RRP genes have been identified as modulators of the p53 or p21 pathway and are therefore therapeutic targets for diseases associated with defective p53 or p21 function. A method is provided for identifying modulators of p53 or p21 comprising screening to look for agents that modulate RRP activity. Modulators identified using the methods of the invention can be used to specifically inhibit the growth of tumor cells that overexpress RRP protein. An mRRP1 knockout mouse is also provided. |