http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005537305-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2003-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005537305-A |
| titleOfInvention | Broad spectrum substituted oxindolesulfonamide HIV protease inhibitors |
| abstract | [Chemical 1] The present invention relates to compounds having the formula (I), their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein R 1 and R 8 are each H, optionally Substituted C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, aryl, Het 1 , Het 2 and R 1 is also of the formula (R 11a R 11b ) NC (R 10a R 10b ) CR 9- may be a group, t is 0, 1 or 2, R 2 is H or C 1-6 alkyl, L is -C (= O)-, -O-C (= O) —, —NR 8 —C (═O) —, —O—C 1-6 alkanediyl-C (═O) —, —NR 8 —C 1-6 alkanediyl-C (═O) —, -S (= O) 2 -, - O-S (= O) 2 -, - NR 8 -S ( O) is 2, R 3 is C 1-6 alkyl, aryl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-4 alkyl or aryl C 1-4 alkyl, R 4 is H, C 1-4 alkyl OC (═O), carboxyl, amino C (═O), mono- or di (C 1-4 alkyl) amino C (═O), C 3-7 cycloalkyl, C 2-6 alkenyl , C 2-6 alkynyl or optionally substituted C 1-6 alkyl, formula (II) is formula (III) or formula (IV), R 5a and R 5b are C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl or C 1-6 alkyl optionally substituted on one or more atoms, R 5a and R 5b are also hydrogen, aryl, Het 1 , Het 2 so R 6 may be hydrogen or C 1-6 alkyl optionally substituted on one or more carbon atoms. It further relates to their use as broad spectrum HIV protease inhibitors, their preparation and pharmaceutical compositions and diagnostic kits comprising them. It also relates to their combination with another antiretroviral agent and their use in the assay as a control compound or reagent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016039403-A1 |
| priorityDate | 2002-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 607.