| abstract |
The present invention describes a novel composition comprising a novel nitric oxide donor and at least one nitric oxide donor. The present invention also provides novel compositions comprising at least one nitric oxide donor and optionally at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The present invention relates to a method for treating cardiovascular diseases, a method for inhibiting platelet aggregation and platelet adhesion caused by exposure of blood to a medical device, a method for treating pathological conditions caused by abnormal cell proliferation; transplant rejection, autoimmunity, inflammation A method for the treatment of sexual, proliferative, hyperproliferative, vascular diseases; a method for reducing scar tissue or inhibiting wound contraction, in particular a method for the prevention and / or treatment of restenosis, wherein at least a nitric oxide donor is selectively used Also provided is a method by administration in combination with one therapeutic agent. The present invention also provides a treatment for inflammation, pain, fever, gastrointestinal disorders, respiratory disorders and sexual dysfunction. Nitric oxide donors donate, transfer or release nitric oxide and / or increase the endogenous level of endothelium-derived relaxing factor and / or stimulate internal synthesis of nitric oxide and / or as a substrate for nitric oxide synthase It is possible to release nitric oxide under physiological conditions or to deliver or move nitric oxide indirectly to the target site. The therapeutic agent may be optionally substituted (ie, nitrosylated and / or nitrosated) with at least one NO and / or NO 2 group. The present invention also provides novel compositions and kits comprising at least one nitric oxide donor and / or at least one therapeutic agent. |