http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005536546-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-05 |
| filingDate | 2002-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005536546-A |
| titleOfInvention | Improved method for the synthesis of (±) 2-amino-N- [2- (2,5-dimethoxyphenyl) -2-hydroxyethyl] acetamide monohydrochloride |
| abstract | The present invention is an improved synthesis method of (±) 2-amino-N- [2- (2,5-dimethoxyphenyl) -2-hydroxyethyl] acetamide monohydrochloride, which comprises 1- (2,5-dimethoxyphenyl It relates to a method of synthesizing from 2-bromoethanone in a good yield and cost-effective manner by reacting with hexamine in the presence of a novel solvent system consisting of tetrahydrofuran and water. The resulting aminoethanone is acylated with haloacetyl chloride and sodium acetate in an acetone-water solvent system. This product is selectively reduced first with sodium borohydride and then with stannous chloride. This product, after its own reduction, is immediately converted into the corresponding hydrochloride salt in the original reaction system. |
| priorityDate | 2002-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.