| abstract |
Formula (1): [Wherein R 1 is —CH 3 , — (CH 2 ) 3 CH 3 , —CH 2 CH 2 OH, —CH 2 CH 2 OCH 3 , —CH 2 CH 2 OCH 2 CH 2 OH, —CH 2 CH 2 OCH 2 CH 2 OCH 3, phenylalanine enamide derivatives is a group of formula (II)], and describing the salts, solvates and N- oxides. The compounds of the present invention are effective and selective inhibitors of oA integrins. This compound is useful in the regulation of cell adhesion and is particularly useful in the prevention and treatment of diseases or disorders involving inflammation involving leukocyte extravasation. The invention extends to such uses and the use of this compound for the manufacture of a medicament for treating such diseases or disorders. |