| abstract |
N is (C 1 -C 6 ) alkyl, (C 3 -C 6 ) alkenyl, 3-oxo- (C 5 -C 6 ) alkyl, 3-oxo- (C 4 -C 6 ) alken-2-yl, Phenyl (C 1 -C 6 ) alkyl, phenyl (C 2 -C 6 ) alkenyl, gem-diphenyl (C 1 -C 6 ) alkyl, gem-diphenyl (C 2 -C 6 ) alkenyl, (C 1 -C 6 ) Alkanoyl, optionally substituted alanyl, N, N ′ optionally substituted ricinoyl, phenyl (C 1 -C 6 ) alkylidene, gem-diphenyl (C 1 -C 6 ) alkylidene substituted R (+)-2-amino-3-hydroxypropionic acid derivatives and pharmaceutically acceptable salts thereof can be used for CNS diseases, particularly autism, schizophrenia, Alzheimer's disease due to decreased glycinergic transmission. For use in the manufacture of a medicament intended for the treatment of. |