http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005535650-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 |
| filingDate | 2003-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005535650-A |
| titleOfInvention | Substituted 4-phenyl-piperidine-amides as tachykinin antagonists and serotonin reuptake inhibitors |
| abstract | The present invention relates to a compound of formula (I): [Chemical 1] [Wherein R represents halogen, C 1-4 alkyl, cyano, C 1-4 alkoxy, trifluoromethyl or trifluoromethoxy; R 1 represents hydrogen, halogen, C 3-7 cycloalkyl, hydroxy, nitro, cyano or halogen, cyano or C 1-4 optionally C 1-4 alkyl optionally substituted by alkoxy,; R 2 represents hydrogen or C 1-4 alkyl; R 3 and R 4, Independently represents hydrogen, cyano, C 1-4 alkyl, or R 3 together with R 4 represents C 3-7 cycloalkyl; R 5 represents trifluoromethyl, S (O) t represents C 1-4 alkyl, C 1-4 alkyl, C 1-4 alkoxy, trifluoromethoxy, halogen or cyano; R 6 represents hydrogen or (CH 2 ) r R 7 ; R 7 represents hydrogen , C 3-7 cycloalkyl, NH (C 1-4 alkyl OC 1-4 Alkoxy), NH (C 1-4 alkyl), represents a N (C 1-4 alkyl) 2, OC (O) NR 9 R 8, NR 8 C (O) R 9 or C (O) NR 9 R 8 R 9 and R 8 independently represent hydrogen, C 1-4 alkyl or C 3-7 cycloalkyl; m represents 0, or an integer from 1 to 4; n represents 1 or 2; P is 0 or an integer from 1 to 3; q is an integer from 1 to 3; r is an integer from 1 to 4; t is 0, 1 or 2; , M is 0, p is 2, q, r and n represent 1 , R 1 , R 2 , R 3 , R 4 , R 5 and R 7 are hydrogen and R is chlorine And R 5 is other than iodine], and pharmaceutically acceptable salts and solvates thereof; methods for their preparation, tachykinin-mediated states and / or It relates to their use in the treatment of conditions mediated by selective inhibition of rotonin reuptake transporter proteins. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012173214-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006525975-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4684221-B2 |
| priorityDate | 2002-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 511.