abstract |
Isolated human monoclonal antibodies that bind to CD30 (eg, human CD30) are disclosed. This human antibody can be produced in a non-human transgenic animal such as a transgenic mouse that can produce human monoclonal antibodies of multiple isotypes by causing V-D-J recombination and isotype switching. In addition, derivatives of the present human antibody (for example, bispecific antibodies and immunoconjugates), pharmaceutical compositions containing the present human antibody, non-human transgenic animals and hybridomas producing the present human antibody, and use of the present human antibody Also disclosed are methods of treatment and diagnosis. |