abstract |
3'-L-valine ester of β-D-2'-C-methyl-ribofuranosyl cytidine provides excellent results against flaviviruses or pestiviruses, including hepatitis C virus. Based on this discovery, a therapeutic compound of Flaviviridae, including HCV, comprising administering an effective amount of val-mCyd or a salt, ester, prodrug or derivative thereof, optionally carried on a pharmaceutically acceptable carrier. , Compositions, methods and uses are provided. In an alternative embodiment, val-mCyd is used to treat any virus that replicates via an RNA-dependent RNA polymerase. |