| abstract |
Compounds of formula I or pharmaceutically acceptable salts thereof (where: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , L 1 , L 2 , M, n, p, X, Y and Z are as described herein); their pharmaceutical compositions, methods of making the pharmaceutical compositions; and their methods of use. The present invention relates to cannabinoid receptor agonists that bind to cannabinoid (CB 2 ) receptors. The compounds according to the invention generally exhibit anti-inflammatory and immunomodulatory activities and in treating irregularly is characterized diseases of inflammation and immunomodulatory useful. Examples of diseases that can be treated include rheumatoid arthritis, asthma, allergy, psoriasis, Crohn's disease, systemic lupus erythematosus, multiple sclerosis, diabetes, cancer, glaucoma, osteoporosis, kidney ischemia, stroke, cerebral ischemia and nephritis However, it is not limited to these. |