| abstract |
A protein ligand comprising an immunoglobulin heavy chain variable (VH) region and an immunoglobulin light chain variable (VL) region, wherein the protein binds to a complex comprising MHC and a peptide, substantially in the absence of the binding peptide. Disclosed are protein ligands that do not bind to MHC, do not substantially bind to peptide in the absence of MHC, and the peptide is a peptide fragment of gp100, MUC1, TAX, or hTERT. Methods of using and identifying such ligands are also disclosed. |