| abstract |
The present invention provides polyanionic polymer conjugates comprising non-nucleotide polyanionic polymers that are useful for detecting target analytes such as proteins or small molecules. The present invention also provides nanoparticles bound to polyanionic polymer composites and methods for making and using the same. The polyanionic polymer composite of the present invention has the following formula: L-O [PO 2 -OZO] n -PO 2 -OX (Wherein n is 1 to 200, L is a moiety comprising a functional group for bonding the polyanionic polymer to the nanoparticle surface, Z is a crosslinking group, X is Q, X ′, or -QX ', Q has a functional group for binding the recognition probe to the polyanionic polymer, and X' is a recognition probe). |