http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005532362-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-405 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 |
| filingDate | 2003-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005532362-A |
| titleOfInvention | Calcium salt of indole-derived statin |
| abstract | The present invention has the formula: Wherein R 1 is alkyl, cycloalkyl or aralkyl; R 2 , R 3 and R 4 are independently hydrogen, halogen or alkyl; R 5 and R 6 are independently hydrogen, Halogen, alkyl, cycloalkyl, aralkyl, alkoxy or aralkoxy; and the hydroxyl group at the 3-position is in the R-configuration and the hydroxyl group at the 5-position is in the S-configuration. ] A calcium salt of an indole-derived statin of formula (IA) represented by formula; or an enantiomer thereof; or a hydrate thereof, which is obtained by the method of the present invention. More particularly, the present invention provides a highly crystalline form of calcium of formula (IA), wherein R 1 is isopropyl, R 2 is fluorine, and R 3 , R 4 , R 5 and R 6 are hydrogen. A salt (referred to herein as fluvastatin calcium) is provided. Furthermore, the present invention relates to a method for producing crystalline fluvastatin calcium and a pharmaceutical composition containing the crystalline form. |
| priorityDate | 2002-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 205.