http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005532281-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48 |
| filingDate | 2003-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005532281-A |
| titleOfInvention | Method for producing morpholine derivative and its intermediate |
| abstract | Formula (IIIA) [Chemical 1] [Where: Z is a bond, CO, SO 2 , CR 10 R 7 (CH 2 ) n , (CH 2 ) n CR 10 R 7 , CHR 7 (CH 2 ) n O, CHR 7 (CH 2 ) n S, CHR 7 ( CH 2) n OCO, CHR 7 (CH 2) n CO, COCHR 7 (CH 2) represents an n or SO 2 CHR 7 (CH 2) n; R 6 is C 1 to 6 alkyl, C 2 to 6 alkenyl, aryl, heteroaryl, aryl -C 2 to 6 alkenyl -, - CN or a group of the formula -Y 2 ~J 3; R 7 is hydrogen, C 1 to 4 alkyl, CONR 8 R 9 or COOC 1 to 6 alkyl A and b represent 1 or 2 and a + b represents 2 or 3; n represents an integer 0-4; M represents a C 3-8 cycloalkyl or C 3-8 cycloalkenyl group fused with a monocyclic aryl or monocyclic heteroaryl group; J 3 represents the formula (K): (wherein X 1 represents oxygen, NR 11 or sulfur, X 2 represents CH 2 , oxygen, NR 12 or sulfur, m 1 represents an integer 1 to 3, and m 2 represents an integer from 1 to 3 (provided that, m 1 + m 2 is in the range of 3-5, also m 1 and when X 1 and X 2 representing the both oxygen, NR 11, NR 12 or sulfur m 2 are both not less than 2.))) where K is optionally one or more (eg 1 or 2) -Y 3 -aryl, -Y 3 -heteroaryl, -Y 3- CO-aryl, -COC 3-8 cycloalkyl, -Y 3 -CO-heteroaryl, -C 1-6 alkyl, -Y 3 -COOC 1-6 alkyl, -Y 3 -COC 1-6 alkyl, -Y 3 -W, -Y 3 -CO-W, -Y 3 -NR 15 R 16 , -Y 3 -CONR 15 R 16 , hydroxy, oxo, -Y 3 -SO 2 NR 15 R 16 , -Y 3 -SO 2 C 1-6 alkyl, -Y 3 -SO 2 aryl, -Y 3 -SO 2 heteroaryl, -Y 3 -NR 13 C 1-6 alkyl, -Y 3 -NR 13 SO 2 C 1-6 alkyl, -Y 3 -NR 13 CONR 1 5 R 16 , —Y 3 —NR 13 COOR 14 or —Y 3 —OCONR 15 R 16 , and optionally fused to a monocyclic aryl or heteroaryl ring; R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and R 14 independently represent hydrogen or C 1-6 alkyl; R 15 and R 16 independently represent hydrogen or C 1-6 alkyl, Or R 15 and R 16 together with the nitrogen atom to which they are attached may form a morpholine, piperidine or pyrrolidine ring; R 17 and R 18 independently represent hydrogen or C 1-6 alkyl. W represents saturated or unsaturated non-substituted containing 1 to 3 heteroatoms selected from nitrogen, oxygen or sulfur, optionally substituted by one or more C 1-6 alkyl, halogen or hydroxy groups Represents an aromatic 5- to 7-membered ring; Y 1 , Y 2 and Y 3 are independently a bond or a formula — (CH 2 ) p CR c R d (CH 2 ) q — (where R c and R d Is independent It represents hydrogen or C 1 to 4 alkyl Te, or R c and R d may form a together with the carbon atom bonded C 3 to 8 cycloalkyl group, and p and q Independently represents an integer 0-5, where p + q is an integer 0-5; and k is 1 or 2] The manufacturing method of the compound represented by these, or its salt is disclosed. |
| priorityDate | 2002-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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