| abstract |
Helical pseudopeptide compounds are provided as inhibitors of β-amyloid formation. These inhibitors preferably cleave intramembrane proteases, particularly amyloid precursor protein (APP), to inhibit aspartyl secretase that produces β-amyloid. Provided are a method for producing a medicament containing the compound and a method for treating β-amyloid-related diseases, particularly Alzheimer's disease. |