abstract |
The present invention provides a solid tumor of a subject comprising: (i) delivering a composition comprising a genetically engineered sheep atadenovirus to the solid tumor; and (ii) administering a prodrug to the subject. A method of treatment, wherein the genetically engineered sheep adenovirus comprises a promoter and a gene encoding an enzyme that converts a prodrug to a cytotoxic metabolite, the gene being under the control of the promoter Provide the method. |