| abstract |
A method is disclosed for a quick and accurate reading of nephrotoxicity before nephrotoxicity occurs and before it is demonstrated by pathological examination. Ultimately, this approach would allow for an initial selection of compounds. The twelve genes identified, calbindin D-28k, KIM-1, OPN, EGF, clusterin, VEGF, OAT-K1, aldolase A, aldolase B, podocin, alpha-2u and C4 were grouped. And ultimately, new compounds can be evaluated in the form of kits using PCR, high throughput techniques, to characterize and position them according to their expected general nephrotoxicity. Also disclosed are methods for identifying agents useful for the treatment of kidney disease, efficacy for treatment of kidney disease and methods for monitoring kidney-specific vectors containing the disclosed gene sequences As well as methods for identifying candidate genes associated with biological processes, including renal function. |