abstract |
The present invention relates to benzoxazines, which are inhibitors of phosphorylation of smad2 or smad3 by the transforming growth factor (TGF) -β signaling pathway, in particular the TGF-β type I or activin-like kinase (ALK) -5 receptor and The invention relates to benzoxazinone substituted triazoles, their preparation and their use in medicine, in particular their use in the treatment and prevention of diseases mediated by the pathway. |