http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005530158-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-557 |
| filingDate | 2003-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005530158-A |
| titleOfInvention | Methods for detecting receptor allosteric effectors |
| abstract | The present invention compares the allosteric effector of a receptor with the dissociation kinetics of the complex formed between the receptor and one of its ligands in the absence of the allosteric effector. Dissociation kinetics of complexes formed between the receptor and the ligand in the presence and / or formation between the receptor and one of its ligands in the absence of the allosteric effector A method of isolation by determining a variation in the amplitude of binding formed between the receptor and the ligand in the presence of the allosteric effector relative to the amplitude of binding formed [the receptor and the The ligand is involved in at least one biological response at appropriate physiological conditions and is allosteric. The effector can modulate at least one of the responses, the receptor is marked with at least one fluorescent protein, and the ligand absorbs light emitted by the fluorescent protein. The step of determining the variation of the dissociation kinetics and amplitude is performed by fluorescence energy transfer, marked with a marker consisting of either the resulting molecule or a fluorescent substance. |
| priorityDate | 2002-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 777.