abstract |
The present invention is directed to general formula I wherein R 1 is hydrogen, (C 1 -C 6 ) -alkyl or hydroxy- (C 1 -C 6 ) -alkyl; R 2 is (C 1 -C 6) - alkyl, -CO-NR 8 R 9, - (CH 2) n -NR 8 R 9, - (CH 2) p -OR 8 or - (CH 2) n be -CN; R 3 is hydrogen, halogen, halogen - (C 1 ~C 6) - alkyl, cyano, C 1 -C 6 - alkoxy or halogen - (C 1 ~C 6) - is selected from alkoxy; R 4, R 5, R 6 and R 7 is hydrogen or fluoro, and at least one of R 4 , R 5, R 6 and R 7 is fluoro; R 8 and R 9 are independently of each other hydrogen or (C 1- C 6) - in Yes alkyl; m is the located 1, 2 or 3; n is 0, 1, 2 or 3; is and p, with 1 or 2) Compounds, and to their pharmaceutically acceptable salts. The compounds of general formula I are selective monoamine oxidase B inhibitors and are therefore suitable for the treatment of Alzheimer's disease or senile dementia. |