| abstract |
The present invention relates to compounds and their derivatives, their synthesis and their use as estrogen receptor modulators. Since the compound of the present invention is a ligand for the estrogen receptor, bone loss, fracture, osteoporosis, cartilage deformation, endometriosis, uterine fibroid, flushing of the face, elevated LDL cholesterol level, cardiovascular disease, cognitive impairment, It may be useful in the treatment or prevention of various conditions related to estrogen function such as cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, particularly breast cancer, uterine cancer and prostate cancer. |