| abstract |
Provided are novel substituted benz-azole compounds, compositions and methods of formula (I) that inhibit Raf kinase activity in human or animal subjects. These novel compounds, compositions, can be used either alone or in combination with at least one additional agent to treat Raf kinase mediated diseases (eg, cancer). The compounds of the invention are useful for the treatment of cancers, which include carcinomas (eg lung cancer, pancreatic cancer, thyroid cancer, bladder cancer or colon cancer), bone marrow diseases (eg myeloid leukemia) and adenomas. (For example, choriocolon adenoma). |