| abstract |
The fluorinated curcuminoid (3,5-bis- (2-fluorobenzylidene) -piperidin-4-one-acetate is about 10 times more effective than cisplatin in arresting tumor cell growth. Provided is a method for delivering a toxic compound (eg, curcuminoid), particularly to vascular endothelial cells that nourish cancer cells and solid tumors, which has a high affinity for proteins (eg, surface protein tissue factor). Tethering the drug to the retained factor VIIa) Upon conjugation, the resulting heterodimer is endocytosed and the drug is degraded within the target cell via proteolytic cleavage. The present invention further provides for the synthesis and efficacy of novel curcuminoid-tether-linker-factor II Va compositions. The amount of novel composition provides a method for delivering to the target tumor or endothelial cells in the patient. |