| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-773
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-265
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-65 |
| filingDate |
2003-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2005-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2005528457-A |
| titleOfInvention |
Compounds that eliminate DNA damage-induced cell cycle G2 checkpoints and / or enhance anti-cancer activity of DNA damage treatment |
| abstract |
The present invention provides compositions and methods for inhibiting cell cycle G2 checkpoints, particularly DNA damage-inducing G2 checkpoints, in mammalian cells, including human cells. In particular, the present invention provides compositions and methods for sensitizing cells to DNA damaging agents by eliminating cell cycle G2 checkpoints. The compounds of the present invention are used to treat proliferative disorders such as cancer. The present invention provides compositions and methods for selectively sensitizing cancer cells weakened at the G1 checkpoint to DNA damaging agents and treatments. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007097010-A1 |
| priorityDate |
2002-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |