| abstract |
The variously substituted carbonate and carbamate derivatives of triptolide compounds have good water solubility and become biologically active compounds in vivo at a rate that can be adjusted by changing the substitution on the prodrug. Convert. The prodrugs are useful as immunosuppressants, anti-inflammatory agents and anticancer agents. The present invention also provides a method for inducing cell death in the treatment of cancer, in particular in the treatment of colon cancer, breast cancer, lung cancer or prostate cancer, inhibition of graft rejection, prevention of graft-versus-host disease. Alternatively, a method is provided that affects immunosuppression, such as treatment or treatment of autoimmune disease. |