| abstract |
alpha 4 integrin (preferably, VLA-4) compounds that bind are disclosed. Also certain of these compounds, leukocyte adhesion, in particular, alpha 4 integrin (preferably, VLA-4) prevents leukocyte adhesion mediated. Such compounds are useful for inflammatory diseases (eg, asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis in mammalian (eg, human) patients. And is useful in the treatment of myocardial ischemia). These compounds can also be administered to treat inflammatory brain diseases (eg, multiple sclerosis). |