| abstract |
【Task】 A new embolizing agent, bioabsorbable polymer material (BPM), is incorporated into the Guglielmi detachable coil (GDC) to improve the long-term anatomical outcome of endovascular treatment of intracranial aneurysms. [Solution] The embolizing agent is composed at least in part of at least one biocompatible and bioabsorbable polymer and growth factor, carried in a hybrid bioactive coil, and in an experimental aneurysm, unorganized clot fibrosis Used to accelerate histopathological conversion to connective tissue. Intravascular cell manipulation and inflammatory responses are elicited from transplantation within vascular regions or intravascular locations. The thrombogenicity of a biocompatible and bioabsorbable polymer is controlled by the composition of the polymer. Furthermore, the coil is at least partly a growth factor, more specifically vascular endothelial growth factor, basic fibroblast. It is composed of cell growth factors or other growth factors. In the illustrated embodiment, the biocompatible and bioabsorbable polymers are polyglycolic acid, polyglycolic acid / poly-L-lactic acid copolymers, polycapractive, polyhydroxybutyrate / hydroxyvalerate copolymers, poly -At least one polymer selected from the group consisting of L-lactide, polydioxanone polycarbonates and polyanhydrides. |