| abstract |
The present invention relates to an adiponectin polypeptide and a conjugate comprising a first non-polypeptide moiety covalently linked to an adiponectin polypeptide, wherein the adiponectin polypeptide has a linking group for the first non-polypeptide moiety Including the amino acid residue, the amino acid residue is introduced at the position occupied by the surface exposed amino acid residue in the original adiponectin. The non-polypeptide moiety can be a polymer such as PEG. Further described is an isolated complex comprising adiponectin trimer and calcium ions. The conjugate or complex is used in the treatment of diseases such as type 2 diabetes, cardiovascular disease, and septic shock. |