| abstract |
One embodiment of the present invention relates to an amine. Another aspect of the invention relates to the use of amines as inhibitors of mammalian anandamide transporters. The compounds of the present invention also have asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, cerebral ischemia, Parkinson's disease, spasticity, Tourette syndrome, schizophrenia, hemorrhagic shock, septic shock , Heart shock, migraine, Horton headache, multiple sclerosis, anorexia, AIDS, wasting syndrome, organ rejection, autoimmune disease, allergy, arthritis, Crohn's disease, malignant glial species, neurodegenerative disease, Huntington's chorea, It finds use in the treatment of a number of diseases, conditions, and diseases that affect mammals, including but not limited to glaucoma, nausea, anxiety, mental illness, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the invention relates to a combinatorial library of amines and a method of making the library. |