| abstract |
The present invention relates to a single nucleic acid vector for gene therapy comprising both adenoviral and retroviral sequences. The vectors described herein transduce all cis and trans components of the retroviral vector, so that recombinant retroviral vectors can be made at high titers. This chimeric vector is used for the delivery and stable integration of therapeutic structures, and overcomes the limitations currently encountered by in vivo gene transfer applications. |