abstract |
The present invention is systematically active as NMDA, 5HT 3 and nicotine receptor antagonists, wherein Formula 1, wherein N, Y, Z, R, R 1 -R 5 are as defined above. Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane represented by the formula, pharmaceutical preparations containing the same, methods for their preparation, and treatment of CNS diseases involved in glutamate transmission disorders, serotonin transmission disorders and nicotine transmission disorders Therefore, it relates to a method of treating with the above compounds for the treatment of immunoregulatory disorders and antimalarial drugs, antitrypanosoma drugs, anti-bornavirus drugs, anti-HSV drugs and anti-hepatitis C drugs. |