| abstract |
The present invention is also known as code number ZD1839, a compound of formula (I): [Chemical 1] Of certain solvates and hydrate crystals. In particular, the present invention provides a first solvate formed in the presence of methanol, denoted as Form 2 ZD1839 MeOH solvate, and a second formed in the presence of dimethyl sulfoxide, denoted as Form 3 ZD1839 DMSO solvate. Solvates and trihydrates formed in the presence of water, designated as Form 5 ZD1839 trihydrate. The present invention further utilizes methods for the preparation of these solvates and trihydrates and methods for converting them back to compound ZD1839, pharmaceutical compositions containing them, and providing antiproliferative effects in cold animals such as humans. For their use in the manufacture of pharmaceuticals. |