| abstract |
Disclosed herein are oral long-term extended release dosage forms (eg, tablets). The oral extended release dosage form comprises an effective amount of a pharmaceutically active compound, at least one amino acid, and a plurality of granules of an intragranular polymer, wherein the hydrophilic extragranular polymer matrix in which the granules are dispersed. This hydrophilic extragranular polymer matrix is hydrated more rapidly than the intragranular polymer. This amino acid is selected for hydropathic properties depending on the solubility properties of the active compound. |