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filingDate 2002-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2005-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2005525128-A
titleOfInvention P53-binding T cell receptor molecules and uses thereof
abstract The present invention provides T cell receptor (TCR) molecules that bind to p53 protein, preferably a peptide derived from human p53 protein. The TCR molecule is a heterodimeric and single-stranded molecule that specifically binds to an amino acid sequence, preferably ranging from about 264 to 272, of the p53 protein presented in the context of an HLA molecule, preferably HLA-A2.1. Is included. Also disclosed are methods of making and using such TCR molecules. The present invention has a wide range of useful applications, including therapeutic use and use in the detection of cells expressing the p53 protein.
priorityDate 2001-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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