| abstract |
General formula (I) (wherein Z is a chain of 7 to 11 α-amino acid residues bound to the template, said amino acid residue being the position of the residue in the chain (starting from the N-terminal amino acid) Depending on the counted position), it is Gly or Pro, or some type of residue, the remaining symbols in the above formula being defined in the specification and claims) The represented template-bound β-hairpin peptide mimetic and its salts have the property of inhibiting proteases, particularly serine proteases. These β-hairpin peptide mimetics can be produced by a method based on a mixed solid phase and liquid phase synthesis method. |