http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005524390-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-527 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2002-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005524390-A |
| titleOfInvention | Methods for identifying inhibitors of asparagine synthase, 5-aminolevulinate synthase, histidinol-phosphatase, 3-isopropylmalate and threonine synthase as antibiotics |
| abstract | The inventors of the present invention have discovered that asparagine synthase, 5-aminolevulinate synthase, histidinol-phosphatase, 3-isopropylmalate dehydratase and threonine synthase are each essential for fungal virulence. Specifically, inhibiting asparagine synthase, 5-aminolevulinate synthase, histidinol-phosphatase, 3-isopropylmalate dehydratase or threonine synthase gene expression in fungi does not result in any sign of successful infection or lesion. Thus, asparagine synthase, 5-aminolevulinate synthase, histidinol-phosphatase, 3-isopropylmalate dehydratase and threonine synthase can be used as targets for identifying antibiotics, preferably antifungal agents. Accordingly, the present invention provides methods for identifying compounds that inhibit asparagine synthase, 5-aminolevulinate synthase, histidinol-phosphatase, 3-isopropylmalate dehydratase or threonine synthase expression or activity. The method of the present invention is useful for identifying antibiotics, preferably antifungal agents. |
| priorityDate | 2001-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1499.