| abstract |
SOLUTION: Formula (1) [Chemical 1] (Wherein R 1 represents an organic group, X represents —CH 2 CH 2 — or —CH═CH—, and R 2 represents a hydrogen atom or an alkyl group), a lactone derivative thereof, A PTX3 gene expression inhibitor containing a salt thereof. [Effect] According to the present invention, a PTX3 gene expression inhibitor useful for the treatment of autoimmune diseases, particularly rheumatoid arthritis, can be obtained. |