http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005522224-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6837 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-00 |
| filingDate | 2003-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005522224-A |
| titleOfInvention | ECIST microarray for screening both DNA hypermethylation and gene silencing, and integrated system for evaluating gene expression, DNA methylation, and histone acetylation using the ECIST microarray |
| abstract | Using arrayed expression CpG island tag (ECIST), DNA methylation and gene expression in cancer cells, as well as DNA methylation, gene expression, and gene-related histone acetylation 3 A new high-throughput method for analyzing one is provided. ECIST corresponds to a genomic DNA fragment containing a GC-rich segment of the gene and a promoter portion and / or exon portion (eg, the first exon). GC-rich segments are useful for screening hypermethylated CpG sites in cancer cells, and the corresponding promoter and exon-containing parts reveal the corresponding transcription levels and assess histone acetylation To help. Confirmation of methylation-dependent gene silencing by identifying highly methylated loci using an ECIST array panel and measuring the expression level of the locus after exposing the cells to a demethylating agent There are also provided high-throughput methods for performing, or identifying high-throughput demethylating agents. In a clearly epigenetic cascade, a high distinction is made between gene up-regulation dependent on direct (primary) demethylation and gene up-regulation dependent on indirect (secondary) demethylation. Further throughput methods are also provided. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11015227-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9127302-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9134237-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9957571-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009523008-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014050404-A |
| priorityDate | 2002-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 497.