| abstract |
A compound comprising a cyclopentanone, cyclopentenone, cyclohexanone or cyclohexenone group, wherein the first ring carbon atom has a —SR substituent, and R optionally has at least one heteroatom in its carbon skeleton. An optionally substituted, unsubstituted, alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl or aralkynyl group, the remaining possible ring carbon atoms may be optionally substituted, and the compound is Than the corresponding cyclohex-2-en-1-one or cyclopent-2-en-1-one derivative in which the —SR group is replaced by a hydrogen atom, (m) Easily soluble in water at a temperature of 20-40 ° C, (n) low lipophilicity and / or (o) high therapeutic index, Or (p) It is difficult to dissolve in water at a temperature of 20-40 ° C, (q) highly lipophilic and / or (r) high therapeutic index, Compound. |