| abstract |
The present invention relates to the collection of immature pancreatic tissue from a mammalian donor and the transplantation of the tissue into the abdominal cavity of a mammalian recipient under conditions where the pancreatic tissue can undergo angiogenesis and maturation, and thereby at least insulin in the recipient. Providing a novel method for tissue and composition for increasing pancreatic mass in a mammalian recipient, comprising growing a functional chimeric pancreatic endocrine section to produce. The present invention also includes not only methods and compositions used to treat pancreatic tissue, recipient immune suppression and recipient costimulation blockade, but also to increase the pancreatic mass of mammalian recipients, Including mammalian immature pancreatic tissue adapted for transplantation. |