| abstract |
The present invention relates to a polynucleotide encoding an immunogenic HIV polypeptide. The use of polynucleotides in applications including immunization, production of packaging cell lines, and production of HIV polypeptides is also described. Polynucleotides encoding antigenic HIV polypeptides are described, and the use of these polynucleotides and polypeptide products derived therefrom (including formulation of immunogenic compositions and their use) is also described. In certain embodiments, the present invention includes HIV polypeptides (Env, Gag, Pol, RT, Int, Prot, Vpr, Vpu, Vif, Nef, Tat, Rev and / or fragments or combinations thereof, Synthetic polynucleotides and / or expression cassettes encoding (but not limited to). |