abstract |
The present invention relates to methods for inhibiting heparanase activity and treating various conditions by administering to an animal an effective amount of an immunogen that elicits an immune response against heparanase. According to the present invention, the immunogen is heparanase or a fragment thereof, preferably the immunogen is an antigen presenting cell (APC) that displays heparanase or a fragment thereof on the surface, such as a dendritic cell (DC). The present invention also relates to a composition containing an immunogen. |