| abstract |
Disclosed is a phosphate transport inhibitor compound represented by Structural Formula (I). R1 and R2 are independently, -H, an electron withdrawing group, or C 1 -C 10 alkyl group. Y is a covalent bond, a substituted methylene group, an unsubstituted methylene group, or —CR1R2P (O) (OH) —. R3 is optionally a hydrocarbyl group containing one or more amine, ammonium, ether, thioether or phenylene linking group, optionally a substituted hydrocarbyl group containing one or more amine, ammonium, ether, thioether or phenylene linking group, heteroaryl group, substituted Heteroaryl group or -Cl, -Br, -F, -CN, -NO 2 , -OR a , -N (R a ) 2 , -COOR a , -CON (R a ) 2 , -COR a , -S (O) R a , -S (O) 2 R a , -S (O) 2 N (R a ) 2 , -NR a S (O) 2 R a , -NR a COR a , halogenated lower alkyl group , An aryl group, a substituted aryl group, or a phenyl group substituted with one or more groups selected from a halogenated alkoxy group. Each R a is independently —H, lower alkyl, substituted lower alkyl, aryl or substituted aryl. Each Rb is independently -H, a lower alkyl group, or a phosphate protecting group. |