abstract |
The present invention relates to the fields of biology, genetics and medicine. In particular, the present invention relates to a novel method for the detection, characterization and / or treatment of neurodegenerative diseases, particularly amyotrophic lateral sclerosis. The invention also relates to a method for the identification or screening of compounds active in the disease. The invention further relates to a compound, gene, cell, plasmid or composition useful for carrying out the method. Specifically, the present invention relates to the role of histone deacetylases, and in particular histone deacetylase 2, in the disease and its use as a therapeutic, diagnostic or experimental target. |