| abstract |
The present invention includes an amino acid that includes an amino acid that is neither a charged amino acid nor C at position 45, and is independently selected from the group consisting of R, G, K, S, Q, L, and P at position 103; A functional heavy chain antibody optionally comprising at least 108 amino acids independently selected from the group consisting of Q, L and R, wherein the position is determined by Kabat numbering, a functional single domain heavy chain antibody; It relates to functional VH domains, or functional fragments thereof. |