| abstract |
N- (substituted) -C- (substituted methyl) -oxazolidinones from optically active C- (protected oxymethyl) -oxazolidinones, C- (substituted methyl) -oxazolidinones, N- (substituted) A process for the preparation of -C- (substituted methyl) -oxazolidinones, preferably chiral, is described. The method can be used to generate combinatorial libraries of the above substituted oxazolidinones or specific substituted oxazolidinones in a two or three step reaction involving multiple reagents that differ in the number of carbons. A number of substituted oxazolidinones produced using the above method have been found to have antimicrobial activity. |