| abstract |
PROBLEM TO BE SOLVED: To provide a drug controlled release system for releasing one or more kinds of active substances into a biological fluid, particularly gastrointestinal fluid, in a certain ratio (that is, zero order), so-called sustained drug release system. A controlled release pharmaceutical formulation having a controlled release rate comprises: (I) Two or more layers of the preparation core, wherein at least one of the layers contains one or more kinds of pharmaceutically active ingredients, and at least one of the layers includes And a formulation core comprising one or more types of release rate controlling polymers; (Ii) a substantially insoluble exterior extending over the tablet core that covers the majority of the surface of the tablet and has an exposed layer that exposes and remains one layer of the formulation core. A sheath, wherein the sheath is electrostatically deposited on the formulation core with a powder comprising fusible particles to form a thin film. |